Preheat your oven to 400°F. Line a baking sheet with parchment paper or lightly grease it.
In a large bowl, combine buttermilk, garlic powder, onion powder, smoked paprika, cayenne pepper, salt, and black pepper. Add the chicken tenderloins and let them marinate for at least 30 minutes (or up to 2 hours in the refrigerator for more flavor).
In a shallow dish, place the flour. In another shallow dish, add the panko breadcrumbs. Remove the chicken from the marinade, allowing excess buttermilk to drip off.
Dredge each piece in flour, shaking off the excess, then dip it back into the buttermilk, and finally coat it with panko breadcrumbs, pressing gently to adhere.
Arrange the coated chicken tenders on the prepared baking sheet. Drizzle olive oil over the top of the chicken tenders.
Bake in the preheated oven for 20-25 minutes, or until the chicken is cooked through and the coating is golden brown and crispy. In the last 5 minutes of baking, brush the chicken with buffalo sauce for extra flavor.
Remove from the oven and let cool for a few minutes before serving. Serve with additional buffalo sauce on the side for dipping.