Preheat the oven to 375°F.
In a large bowl, combine the shredded chicken, buffalo sauce, cream cheese, cheddar cheese, green onions, garlic powder, onion powder, salt, and black pepper. Mix until well combined.
Open the can of biscuit dough and separate the biscuits. Flatten each biscuit into a circle about 4 inches in diameter.
Place about 2 tablespoons of the buffalo chicken mixture in the center of each flattened biscuit.
Fold the edges of the biscuit over the filling and pinch to seal tightly, forming a ball.
Place the biscuit bombs seam-side down on a greased baking sheet.
Spray the tops lightly with cooking spray and bake for 15-20 minutes or until golden brown.
Let cool for a few minutes before serving.